Selectins: Adhesion Molecules with Multiple Carbohydrate Ligands.

Targeting Selectins and Their Ligands in Cancer

Aberrant glycosylation is a hallmark of cancer cells with increased evidence pointing to a role in tumor progression. In particular, aberrant sialylation of glycoproteins and glycolipids has been linked to increased immune cell evasion, drug evasion, drug resistance, tumor invasiveness, and vascular dissemination, leading to metastases. Hypersialylation of cancer cells is largely the result of ...

Selectins: critical mediators of leukocyte recruitment.

Selectins are multi-functional adhesion molecules that mediate the initial interactions between circulating leukocytes and the endothelium. First identified over a decade ago, selectins have provided insight into areas as diverse as normal lymphocyte homing, leukocyte recruitment during inflammatory responses, carbohydrate ligand biosynthesis and adhesion-mediated signalling. This review will e...

Signal transduction and signal modulation by cell adhesion receptors: the role of integrins, cadherins, immunoglobulin-cell adhesion molecules, and selectins.

Selectins: a family of adhesion receptors.

Recent data have shown that a group of cell surface proteins, originally studied independently as lymphocyte homing receptors or as activation-induced surface proteins of platelets and/or endothelial cells (Stoolman, 1989) are structurally related. Each is an integral membrane protein with an N-terminal, C-type lectin domain followed by an EGF-like module, multiple copies of the consensus repea...

Leukocyte adhesion: Two selectins converge on sulphate

The selectins are a family of cell–cell adhesion proteins that participate in leukocyte–endothelial and leukocyte– platelet interactions [1–4]. The family consists of three members: P-selectin, expressed on activated endothelium and platelets; E-selectin, expressed on activated endothelium; and L-selectin, expressed on circulating leukocytes (Fig. 1). During the process of leukocyte emigration ...